Long-term outcomes of severe childhood malnutrition study

Medium- and long-term health outcomes of adolescents and young adults following severe malnutrition in childhood: A longitudinal cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN17238083

Enrollment

350

Registered

2021-06-08

Start date

2021-08-01

Completion date

Unknown

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health outcomes of severe childhood malnutrition Other

Interventions

We will contact all previous participants (cases, sibling controls and community controls with additional controls if required) to ask them to come for a half-day assessment in Blantyre, Malawi. Recru

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Previous recruitment to the ChroSAM study

Exclusion criteria

Exclusion criteria: 1. Controls that have significant health issues 2. Previous participants that are unavailable (for example, have moved far from previous recruitment area in Blantyre) since last follow-up

Design outcomes

Primary

Measure	Time frame
Survival is measured using a follow-up questionnaire of participants 8 years following the previous ChroSAM study	—

Secondary

Measure	Time frame
1. Body composition is measured using body impedance analysis and skinfold thickness at 8 year follow-up 2. Growth is measured using anthropometry (mean upper arm circumference, weight, height, hip circumference, sitting height) at 8 year follow-up 3. Cardiovascular disease risk is measured using resting blood pressure at 8 year follow-up 4. Cardiovascular disease risk is measured using lipidomic analysis at 8 year follow-up 5. Metabolic disease risk is measured using oral glucose tolerance test at 8 year follow-up 6. Metabolic disease risk is measured using metabolomics at 8 year follow-up 7. Chronic stress is measured using hair cortisol at 8 year follow-up 8. Motor function is measured by hand grip strength, exercise tolerance and rapid consequential movements at 8 year follow-up 9. Cognition is measured by a tablet-based cognition assessment (CANTAB) and school performance at 8 year follow-up. 10. Cognition and inattention is measured with EEG and eye tracking at 8 year follow-up 11. Mental health & behaviour is measured using strengths & difficulties, GAD-7, PHQ-9 and child behaviour checklist questionnaires at 8 year follow-up	—

Measure

Time frame

1. Body composition is measured using body impedance analysis and skinfold thickness at 8 year follow-up 2. Growth is measured using anthropometry (mean upper arm circumference, weight, height, hip circumference, sitting height) at 8 year follow-up 3. Cardiovascular disease risk is measured using resting blood pressure at 8 year follow-up 4. Cardiovascular disease risk is measured using lipidomic analysis at 8 year follow-up 5. Metabolic disease risk is measured using oral glucose tolerance test at 8 year follow-up 6. Metabolic disease risk is measured using metabolomics at 8 year follow-up 7. Chronic stress is measured using hair cortisol at 8 year follow-up 8. Motor function is measured by hand grip strength, exercise tolerance and rapid consequential movements at 8 year follow-up 9. Cognition is measured by a tablet-based cognition assessment (CANTAB) and school performance at 8 year follow-up. 10. Cognition and inattention is measured with EEG and eye tracking at 8 year follow-up 11. Mental health & behaviour is measured using strengths & difficulties, GAD-7, PHQ-9 and child behaviour checklist questionnaires at 8 year follow-up

—

Countries

Malawi

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026