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Can squeezing blood from the umbilical cord into the baby reduce death and illness in premature babies?

Impact of one-time umbilical cord milking after cord cutting on morbidity and mortality of extremely preterm infants

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN17228884
Enrollment
100
Registered
2018-11-15
Start date
2015-12-26
Completion date
Unknown
Last updated
2021-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm baby (less than 30 weeks of gestational age) Pregnancy and Childbirth

Interventions

This study is held in a single centre. After informed consent has been provided the parents, the baby will be randomly assigned to one of two groups, the milking group and the clamping group. After th

Sponsors

MacKay Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Preterm (born at less than 30 weeks of gestational age)

Exclusion criteria

Exclusion criteria: 1. Known congenital anomaly 2. Fetal anemia 3. Hydrops fetalis 4. Unknown specific gestational age 5. Umbilical cord is less than 20 cm long 6. Received resuscitation after birth and receiving one or more doses of epinephrine

Design outcomes

Primary

MeasureTime frame
1. Neonate's hemoglobin level at admission 2. Neonate's hematocrit at admission 3. Neonate's mean arterial pressure at admission 4. Administration of inotropic agents in first 72 h post-birth All data will be taken from medical records.

Secondary

MeasureTime frame
1. Rate of death before post-menstrual age (PMA) of 36 weeks assessed by reviewing the patient’s medical records 2. Rate of bronchopulmonary dysplasia assessed by reviewing the patient’s medical records 3. Rate of all-stage intraventricular hemorrhage assessed by reviewing the patient’s medical records 4. Rate of severe intraventricular hemorrhage assessed by reviewing the patient’s medical records 5. Rate of necrotizing enterocolitis assessed by reviewing the patient’s medical records 6. Rate of retinopathy of prematurity assessed by reviewing the patient’s medical records Neonates will be followed up from birth until first discharge from hospital.

Countries

Taiwan

Contacts

Public ContactShang Po Shen

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026