Unilateral hippocampal sclerosis post standard anterior temporal lobe resection Nervous System Diseases
Conditions
Interventions
The present study is a randomized controlled study with follow up after 6 months. It consists of two study groups (the intervention group and the treatment as usual group [TAU]) and one comparison gro
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients: 1. Patients diagnosed with DRE with HS or dual pathology (FCD) within the resected area as determined by pre-surgical imaging and other neurological examinations from the neurosurgery inpatient and outpatient services of NIMHANS 2. Patients who have subsequently undergone ATL-AH and are stabilized on anti-epileptic drugs (AEDs) over a period of 6 months to 7 years post-surgery 3. Patients with 1A outcome of surgery on Engel’s classification system 4. Patients within 18 to 50 years of age 5. Patients who are right-handed 6. Patients with at least the ability to read and write in one language 7. Patient with language fluency in Hindi, English or Kannada 8. Patients with adequate/corrected auditory, visual and/or motor function Healthy controls: 1. Individuals matching with the Intervention group participants on gender, age and education within ±2 SD range 2. Individuals within 18 to 50 years of age 3. Individuals who are right handed 4. Individuals with and ability to read and write in one language 5. Individuals with language fluency in Hindi, English or Kannada 6. Individuals with adequate/corrected auditory, vision and sensory-motor functions
Exclusion criteria
Exclusion criteria: Patients: 1. Patients diagnosed as having double pathology or extra-temporal pathology 2. Patients who have undergone surgery before the age of 12 years 3. Patients who have undergone multiple surgeries for epileptic seizures or any other neurological condition 4. Patients with any outcome of seizure other than 1A on Engel’s classification system 5. Patients with a history of intellectual disability 6. Patients who have undergone any form of psychological intervention 7. Patients with any other neurological, medical and psychiatric conditions including substance abuse Healthy controls: 1. Individuals with a history of intellectual disability 2. Individuals who have undergone any form of psychological intervention. 3. Individuals with any other psychiatric (including substance abuse) and neurological conditions 4. Individuals with a history of medical conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Neuropsychological variables measured using a combination of selected subtests from the WMS III IND, NIMHANS Neuropsychological Battery for Adults and D-KEFS subtests at baseline, 20 days to 1 month, and 6 months from the last assessment 2. Quality of life measured using QOLIE-31 at baseline, 20 days to 1 month and 6 months from the last assessment 3. Mood states of anxiety measured using GAD-7 and depression using PHQ-9 at baseline, 20 days to 1 month and 6 months from the last assessment 4. Diffusion tensor imaging for a selected group of participants using 3T-MRI at baseline and 20 days to 1 month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Left versus right ATL-AH neuropsychological profiles measured using a combination of WMS III IND, NIMHANS Neuropsychology Battery for Adults and DKEFS subtests at baseline 2. Neuropsychological variables compared between the intervention group and the healthy control group using WMS III IND, NIMHANS Neuropsychology Battery for Adults and D-KEFS subtests to establish gains/deficits post retraining at baseline and after the intervention 3. Levels of cognitive estimation/subjective confidence levels in intervention and treatment-as-usual groups measured using subjective confidence ratings at baseline, 2nd assessment and follow-up | — |
Countries
India
Contacts
Public ContactJasmine Pasricha
Outcome results
None listed