Osteoporosis, Osteopenia Musculoskeletal Diseases Osteoporosis
Conditions
Interventions
1. One group will receive the Osteofit exercise programme alone
2. Another group will receive the Osteofit exercise programme in addition to whole body vibration therapy
3. The protocol for the Osteof
Sponsors
University College Dublin (Ireland)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women between 55 and 80 years of age 2. Diagnosis by DXA scan with osteopenia or osteoporosis
Exclusion criteria
Exclusion criteria: 1. Functional disability/pathology preventing participation in the intervention 2. Cognitive impairment questioning the ability to give informed consent/follow trial protocol 3. Lack of spoken and/or written English impairing ability to give informed consent/follow trial protocol 4. Medical conditions/contraindications to a moderate functional exercise programme according to the American College of Sports Medicine 5. Mobility limitations hampering travel for assessments as well as the exercise programme 6. Those already engaged in high impact activity at least twice a week (any weight bearing exercise or activity more intense than brisk walking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Blood serum tests for biochemical products of bone formation will be taken, by venipuncture in the phlebotomy department of an affiliating university hospital. Serum procollagen type 1 N-terminal peptide (P1NP) and Serum collagen type 1 cross-linked C-telopeptide (CTX) will be used as markers for bone formation and resorption, respectively. 1.2. Blood samples will be taken between 8am - 11am after a 12 hour fast 2. BMD will be tested by DXA (GE Lunar iDXA, Madison WI, USA) 2.1. Subjects will wear light clothing and remove all metal prior to scan 2.2. Scans will be taken at lumbar spine (L 1-4), non dominant hip (femoral neck and trochanter) and non dominant wrist (distal radius and ulna) of each participant 2.3. Standard positioning will be used with anterior posterior scans 2.4. The heights of the regions of interest (ROI) used in the DXA analysis will be adjusted to be anatomically comparable. All scan analyses, quality assurance and phantom spine calibration procedures will be performed daily prior to scanning sessions by the same technician, to ensure repeatability of the measures | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The Five Times Sit to Stand Test (FTSTS) will be used to determine functional lower limb strength 1.1. The subjects will stand up and sit down 5 times as quickly as possible and their time will be measured using a digital stop watch 1.2. They will be asked to repeat this three times with the average of the three scores being recorded 1.3. The height of the chair will be standardised to 43cm from seat to floor, with no arm rests 1.4. Subjects will be instructed not to use hands for support on their legs or chair 1.5. All participants will undergo one set of 5 sit to stands as a familiarisation trial prior to the test 2. Dynamic balance will be measured barefoot using the Star Excursion Balance Test (SEBT) 2.1. The anterior, posteromedial, and posterolateral directions of the SEBT will be used 2.2. Three consecutive trials in each direction will be performed and the average value obtained in each direction taken as the score 2.3. Participants will be required to reach as far as possible along the directional component of the SEBT (i.e. anterior, posteromedial, or posterolateral direction) and make a light touch with the foot 2.4. All participants will be instructed to perform three familiarisation trials in each direction prior to the test commencing 3. Maximal isometric strength of leg extensors will be measured using a myometer (M.I.E. Medical Research, Yorkshire, UK.) 3.1. Subjects will sit with their knees and ankles at an angle of 90° of flexion while pressing maximally against the myometer 3.2. The isometric strength of the non dominant leg will be recorded for three maximal efforts and the average of the three readings will be used as a test score 4. Grip Strength will be measured using a standard grip strength dynamometer (M.I.E. Medical Research, Yorkshire, UK.) 4.1. The average of three readings from the non dominant hand will be used as a test measure 4.2. The physical tests will be preceeded by one familiarisation trial (one in each direction for the b | — |
Countries
Ireland
Outcome results
None listed