Determination of the rate of gastric emptying of two different types of fluid in healthy volunteers Digestive System
Conditions
Interventions
16 healthy volunteers will ingest 500 ml of one of 4 different fluids after an overnight fast. Changes in gastric cross-sectional area are monitored repeatedly for four hours using gastric ultrasound.
Sponsors
Uppsala University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy adults without ongoing medication or medical condition associated with delayed gastric emtpying
Exclusion criteria
Exclusion criteria: 1. Diabetes 2. Gastrointestinal motility disorder 3. Pregnancy beyond the 2nd trimester 4. Medications that delay gastric emptying 5. Previous abdominal surgery 6. Morbid obesity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric antral surface area (cm2) Measurement method: the abdomen is scanned with a curvilinear probe, the antrum is identified in the same plane as either the aorta, the superior mesenteric artery or the lower vena cava. The image is frozen antd the cross-sectional area (CSA) is delineated using the ultrasound machine's internal software application. Measurements are taken at baseline (before ingestion of study drink), and up to 360 minutes after ingestion if needed, but until the antral CSA reaches baseline +/- 5%. | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastric antral surface area (cm2) measured as above at baseline and 10, 20, 30, 40, 50, 60, 100, 140, 180, 210, 240, 270, 300, 330 minutes after ingestion | — |
Countries
Sweden
Outcome results
None listed