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Youth-GEMS: Understanding genetic and environmental interactions in youth mental health

Gene-Environment interactions in Mental health trajectories of Youth (Youth-GEMs Cohort)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN17131459
Enrollment
1000
Registered
2024-01-30
Start date
2024-03-02
Completion date
Unknown
Last updated
2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-chronic emerging mental health symptoms Mental and Behavioural Disorders

Interventions

Current methodology as of 04/02/2026: Participants will be referred to the study by experienced mental health professionals. If they agree to participate, research staff will cite them in-site for inf

Sponsors

Hospital General Universitario Gregorio Marañón
Lead Sponsor
University of Edinburgh
Collaborator
University of Split
Collaborator
Clinic for Neurology and Psychiatry for Children and Youth
Collaborator
Maastricht University
Collaborator
Tartu Ulikool
Collaborator

Eligibility

Sex/Gender
All
Age
12 Years to 24 Years

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 04/02/2026: 1. Age between 12-24 years 2. New appointment with a mental health service within the past 2 months 3. Good command of the languages used in the study, as most of the clinical assessment will be based on self-reported questionnaires 4. Written informed consent by the participant, their parents if minors, or legal representatives if appropriate Previous inclusion criteria: 1. Aged 12-24 years 2. Less than 1 month from the first contact with mental health services 3. Good command of the languages used in the study 4. Written informed consent by the participant and their parents and legal representatives, when appropriate

Exclusion criteria

Exclusion criteria: Current exclusion criteria as of 04/02/2026: 1. Previous contact with a mental health service at the same level of care (primary, secondary, tertiary, quaternary) within the past 12 months 2. Intellectual disability with associated functional impairment 3. Severe neurological or medical condition 4. Genetically confirmed neurobehavioral syndromes 5. Significant difficulties in completing the self-reported questionnaires Previous exclusion criteria: 1. Intellectual disability with associated functional impairment 2. Severe neurological or medical condition 3. Genetically confirmed neurobehavioral syndromes 4. Significant difficulties in completing the self-reported questionnaires

Design outcomes

Primary

MeasureTime frame
Quality of life, with general wellbeing, daily functioning, relationships with friends, relationships with family and coping as subdomains, measured with the MyLifeTracker outcome measure at baseline, 3, 6, 12, 18 and 24 months follow-up

Secondary

MeasureTime frame
Current secondary outcomes as of 04/02/2026: Clinical dimensions: 1. Anxiety and depression measured with the RCADS at baseline, and 3, 6, 12, 18 and 24 months follow-up 2. Distress tolerance measured with the DTS-short at baseline, and 3, 6, 12, 18 and 24 months follow-up 3. Current mania measured with the Altman Self-rating Mania Scale (ASRM) and Rapid Mood Screener (RMS) at baseline, and 3, 6, 12, 18 and 24 months follow-up 4. Psychotic-like symptoms measured with the Psychosis Experiences Inventory (PEI) at baseline, and 3, 6, 12, 18 and 24 months follow-up 5. Dissociative symptoms measured with the Dissociative Experiences Scale (DES) at baseline, and 6, 12, and 24 months follow-up 6. Suicidality measured with the Columbia Suicide Severity Rating scaleat baseline, and 24 months follow-up 7. Non-suicidal self-harm measured at baseline, and 24 months follow-up 8. General psychopathology measured with the Strengths and Difficulties Questionnaire (SDQ) at baseline, and 3, 6, 12, 18 and 24 months follow-up 9. Eating disorders measured with the Eating Disorder Screen for Primary Care at baseline, 12, and 24 months follow-up 10. Obsessions and intrusive thoughts measured with the Children’s Obsessional Compulsive Inventory Revised (ChOCI-R) at baseline, and 3, 6, 12, 18 and 24 months follow-up 11. Stressful life events measured with an ad-hoc questionnaire at baseline, 12, and 24 months follow-up 12. Childhood Trauma measured with the Childhood Trauma Questionnaire - Short version, Juvenile Victimization Questionnaire (JVQ), and Childhood Experience of Care and Abuse (CECA) at baseline 13. Bullying and cyberbullying measured with an ad-hoc questionnaire at baseline. 14. PTSD symptoms measured with the UCLA PTSD Reaction Index for DSM-5 Brief form at baseline. 15. Family and social environment measured with an ad-hoc questionnaire at baseline and 12 and 24-month follow-up. 16. Parental bonding measured with the Relationship Structures (ECR-RS) questionnaire and peer bo

Countries

Croatia, Estonia, Finland, Netherlands, Serbia, Spain

Contacts

Public ContactRenzo Abregú-Crespo
renzo.abregu@iisgm.com+34 (0)914265095

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026