Heart failure or those with left ventricular diastolic dysfunction but without clinical symptoms or signs of heart failure Circulatory System
Conditions
Interventions
Measurements are taken on one occasion. Non-invasive ultrasound measurements will be performed on participants with ECG monitoring. Measurements at the radial, brachial and carotid artery will be atte
Sponsors
Imperial College Healthcare NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers: 1. Members of staff who are clinically well Patients: 1. Patients with heart failure and left ventricular systolic impairment (ejection fraction, measured by biplane Simpsons methodology on echocardiography, 50%) 3. Patients without clinical symptoms or signs of heart failure but with left ventricular diastolic dysfunction with an E/E’ ratio of 15+
Exclusion criteria
Exclusion criteria: 1. Known arrhythmias 2. Hypertension (except for the hypertensive control group) 3. Hyperlipidemia 4. Aneurysm 5. Diabetes 6. Heart failure 7. Taking medication for cardiovascular conditions 8. Lack capacity to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At a single time point: 1. Wave intensity metrics obtained from non-invasive ultrasound measurements taken from the carotid, brachial and radial arteries using a range of ultrasound scanners (At present, a research ultrafast scanner is used.) 2. Routinely collected transthoracic echocardiography data using patient records. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed