Chronic kidney disease Urological and Genital Diseases Kidney disease
Conditions
Interventions
Sodium bicarbonate versus no treatment.
Duration of treatment: 2 years
Method of intake: oral
Frequency of treatment: daily 600 mg three times a day to be titrated up by 600 mg till serum biocarbona
Sponsors
Barts and the London NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age greater than 18 years old 2. CKD stage 4 and 5 3. Mild to moderate metabolic acidosis (serum bicarbonate less than 21 and greater than 16 mmol/L) on two consecutive measurements 4. Stable clinical condition
Exclusion criteria
Exclusion criteria: Patients with: 1. Malignant disease 2. Morbid obesity 3. Cognitive impairment 4. Chronic sepsis 5. Poorly controlled blood pressure (greater than 150/90 mmHg), despite use of four agents 6. Overt congestive heart failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end points were number of patients reaching ESRD and rate of decline of estimated glomerular filtration rate (eGFR) by Cockroft-Gault equation and creatinine clearance (Cr Cl) (24 hours urine sample). Primary end points are measured every three months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional parameters assessed by: 1. Dietary protein intake 2. Protein catabolic rate (PCR) 3. Serum albumin 4. Mid-arm muscle circumference (MAMC) Secondary end points measured every six months. | — |
Countries
United Kingdom
Outcome results
None listed