Casein+ study: Dietary strategies to augment post-prandial muscle protein accretion

Dietary strategies to augment post-prandial muscle protein accretion: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17091496

Enrollment

Registered

2012-10-10

Start date

2011-01-01

Completion date

Unknown

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia Musculoskeletal Diseases Muscle wasting and atrophy, not elsewhere classified

Interventions

1. 20 g intrinsically labeled casein protein only in healthy elderly men 2. 20 g intrinsically labeled casein protein with 40 g of carbohydrate in healthy elderly men 3. 20 g intrinsically labeled cas

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Males 2. Age 70-85 years or age 18-30 years 3. Body mass index (BMI) < 30 kg·m^2

Exclusion criteria

Exclusion criteria: 1. Type II diabetes 2. All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis) 3. Use of anticoagulants, blood diseases, allergy for lidocain 4. Use of Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid 5. Patients suffering from Phenylketonuria (PKU) 6. Participation in any regular exercise program

Design outcomes

Primary

Measure	Time frame
1. Muscle protein synthesis rate 2. Muscle biopsy at t=0 (before drink), t=120 and t=360 min	—

Secondary

Measure	Time frame
Plasma glucose, insulin, and amino acid concentrations. Blood draws at t=0 (before drink), 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 and 360 min	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026