ADAM: Alcohol dependence and adherence to medicine

A three-arm randomised controlled trial of the effectiveness and cost-effectiveness of adjunctive medication management and contingency management to enhance adherence to medications for relapse prevention in alcohol dependence

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17083622

Enrollment

748

Registered

2015-09-16

Start date

2015-09-30

Completion date

Unknown

Last updated

2023-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol dependence Mental and Behavioural Disorders Mental and behavioural disorders due to use of alcohol

Interventions

Contingency Management (CM), Providing small financial or other incentives to change behaviour and/or engage with treatment. Incentives in the form of vouchers will be provided to rein

Medication Management (MM), MM is an intervention to help improve medication and treatment adherence by providing education, support and advice to patients about their drinking behaviours and medicati

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or over 2. Diagnosis of alcohol dependence 3. Currently alcohol abstinent 4. Prescribed acamprosate by treating clinician

Exclusion criteria

Exclusion criteria: 1. Severe physical/mental illness likely to preclude active participation in treatment or follow up 2. Current participation in another trial 3. Unable to adequately understand verbal English 4. Currently dependent on an illicit substance

Design outcomes

Primary

Measure	Time frame
Proportion of medication taken as prescribed measured using Medication Events Monitoring (MEMS) Cap, pill count and self reporting over 24 weeks.	—

Secondary

Measure	Time frame
1. Alcohol related problems, severity of dependence and cravings measured using the alcohol problems questionnaire (APQ), the severity of alcohol dependence questionnaire (SADQ) and the Alcohol Urge Questionnaire (AUQ) 6 months post randomisation 2. Economic status measured using the Health related Quality of life (EQ-5D-5L) and Adult service use (modified ADSUS) at 6 and 12 months 3. Process outcomes measured using beliefs about medication questionnaire (BMQ) at baseline and 6 months, and scale to assess relationships (STAR) at 6 months 4. Proportion of prescribed medication taken measured using self reporting at 12 months post randomisation 5. Time to first drink, relapse to heavy drinking, relapse to any drinking measured using self reporting at 12 months post randomisation 6. Total alcohol consumed, drinks per drinking day and percentage of abstinence measured over the past 90 days using the timeline follow-back method at 6 and 12 months post randomisation	—

Measure

Time frame

1. Alcohol related problems, severity of dependence and cravings measured using the alcohol problems questionnaire (APQ), the severity of alcohol dependence questionnaire (SADQ) and the Alcohol Urge Questionnaire (AUQ) 6 months post randomisation 2. Economic status measured using the Health related Quality of life (EQ-5D-5L) and Adult service use (modified ADSUS) at 6 and 12 months 3. Process outcomes measured using beliefs about medication questionnaire (BMQ) at baseline and 6 months, and scale to assess relationships (STAR) at 6 months 4. Proportion of prescribed medication taken measured using self reporting at 12 months post randomisation 5. Time to first drink, relapse to heavy drinking, relapse to any drinking measured using self reporting at 12 months post randomisation 6. Total alcohol consumed, drinks per drinking day and percentage of abstinence measured over the past 90 days using the timeline follow-back method at 6 and 12 months post randomisation

—

Countries

England, United Kingdom

Contacts

Public ContactKim Donoghue

kim.donoghue@ucl.ac.uk+44 (0)20 7679 1897

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 8, 2026