Infertility and PCO. Pregnancy and Childbirth Infertility and polycystic ovaries
Conditions
Interventions
hCG-injection vs no injection 36 hours before aspiration of oocytes.
Randomization is performed by a nurse two days before aspiration of immature oocytes. Block randomization is used, at a size of 50
Sponsors
Odense University Hospital (Denmark)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women with PolyCystic Ovaries (PCO) according to Rotterdam criteria (2003) 2. Referred to the Fertility Clinic, Odense University Hospital 3. Candidates for IVF-treatment according to the standards of the Fertility Clinic
Exclusion criteria
Exclusion criteria: 1. Normal ovarial morphology 2. Manifest diseases requiring medication e.g. diabetes mellitus 3. Endocrine diseases, e.g. hyperprolactinaemia, hyper-and hypothyroidism 4. Abuse of drugs or alcohol 5. More than two previous IVF treatments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measures amended as of 26/06/2007: 1. Maturation rate (number of mature [M2] oocytes per number of aspirated oocytes) at 30 and 46 hours 2. Fertilization rate (number of fertilized oocytes per number of matured oocytes) at 46 and 70 hours Primary outcome measures provided at time of registration: 1. Maturation rate (number of mature [M2] oocytes per number of aspirated oocytes) 2. Fertilization rate (number of fertilized oocytes per number of matured oocytes) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures amended as of 26/06/2007: 1. Number of transferable embryos with normal development on day 2 after fertilization, as a fraction of aspirated, matured and fertilized oocytes in IVF and Intra Cytoplasmatic Sperm Injection (ICSI) groups 2. Maturation rate in relation to follicle size (46 hours after maturation) 3. Maturation rate in relation to serum concentrations of various hormones, measured on various cycle days and days of randomization and aspiration Secondary outcome measures provided at time of registration: 1. Number of transferable embryos with normal development on day 2 after fertilization, as a fraction of aspirated, matured and fertilized oocytes in IVF and Intra Cytoplasmatic Sperm Injection (ICSI) groups 2. Maturation rate in relation to follicle size 3. Maturation rate in relation to serum concentrations of various hormones, measured on various cycle days and days of randomization and aspiration | — |
Countries
Denmark
Outcome results
None listed