Paediatric lower respiratory tract infections Infections and Infestations
Conditions
Interventions
Stratified by centre and type of LRTI, patients will be randomised to management according to internationally recognised guidelines ("guideline group") versus PCT-guided AB therapy ("PCT group"). In t
Sponsors
University Children's Hospital Basel (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Both males and females, 1 month to 18 years of age 2. Two pre-specified sub-groups will be recruited: 2.1. Patients with acute LRTI based on clinical diagnosis 2.2. Patients with X-ray confirmed community acquired pneumonia (CAP)
Exclusion criteria
Exclusion criteria: 1. Patients who have been hospitalised within the previous 14 days 2. Patients with immune-suppression, chronic infection, or a terminal condition 3. Patients lacking informed consent 4. Insufficient knowledge of German (in a family member)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antibiotic prescription rate at Day 1, 3, 5 and 14. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time to recovery (days with restriction from LRTI) 2. Rate and duration of hospitalisation 3. Complication rate 4. Measures of laboratory and clinical outcome 5. Side effects from AB 6. Disease activity scores Endpoints will be assessed at day 1, 3 and 5 in the form of a medical consultation at the hospital, and after 14 days by structured phone interviews conducted by blinded investigators. | — |
Countries
Switzerland
Outcome results
None listed