Sickle cell disease Haematological Disorders
Conditions
Interventions
Adolescents attending the four selected hospitals will be randomized into either an intervention or control group. Every adolescent and their caregiver who meets the inclusion criteria will be contact
Sponsors
Carnegie-University of Ghana BANGA Project
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adolescents aged 10-19 years 2. Confirmed diagnosis of SCD and who are appropriately described to be ‘in a steady state’ (no history of stroke or long-term transfusion therapy for at least 4 weeks before the intervention, no hospitalization or intercurrent illness that required emergency or hospitalization 4 weeks before the study) 3. No other chronic disorder
Exclusion criteria
Exclusion criteria: Receiving any treatment that has a direct impact on growth e.g. hydroxyurea
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in fat-free mass assessed using a bioelectrical impedance analyzer device (Omron (BF511) and the Fourier-transform infrared spectroscopy instrument, which determines the percentage fat and fat-free mass at baseline and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Knowledge, Attitude, Practices and Perception (KAPP) scores of all the adolescents using the FAO KAPP questionnaire 2. Disease Severity Index Scores calculated from number of recurrences (frequency of painful crises, hospitalization and blood transfusion over the past 6 months), laboratory values (haemoglobin level, bilirubin level, proportion of foetal haemoglobin (HbF), lactate dehydrogenase (LDH) level and leucocyte count) and disease complications (acute chest infection/syndrome, leg ulcers, gallstones, stroke, avascular osteonecrosis, osteomyelitis, enuresis, priapism, retinopathy, and deep vein thrombosis) 3. Stunting (height for age) assessed using using WHO AnthroPlus software 4. Wasting (weight for height) assessed using using WHO AnthroPlus software 5. Underweight (weight for height) assessed using using WHO AnthroPlus software 6. Nutrient intake and dietary diversity scores assessed using 24-hour recall and Food Frequency Questionnaire analyzed using the Esha FPro 3.2 and RIING database All outcome measures were measured at baseline and endline (6 months). | — |
Countries
Ghana
Outcome results
None listed