Effects of complete fasting on human health and metabolism Nutritional, Metabolic, Endocrine
Conditions
Interventions
10-day water-only fasting in a controlled building including 3-day baseline (BL), 10-day complete fasting (CF), 4-day calorie restriction (CR) and 5-day full recovery (FR). Health status is assessed b
Sponsors
State Key Laboratory of Space Medicine Fundamentals and Application and the China Astronaut Research and Training Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy male 2. 25-55 years old 3. BMI 20-32 kg/m²
Exclusion criteria
Exclusion criteria: 1. Malignant tumor 2. Serious cardiovascular diseases (congenital heart disease, myocardial infarction, coronary heart disease, angina pectoris, etc) 3. Infectious disease 4. Mental disorders 5. Anemia 6. Hypotension 7. Diabetes mellitus 8. History of gastrointestinal ulcer 9. Other after medical examination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Body weight is measured by an electric scale every day throughout the study 2. Blood pressure is measured by an electronic blood pressure monitor every day throughout the study 3. Blood glucose and ketone determined by test strip every day or by a biochemistry method at six timepoints (3 days before fasting, the 3rd day, 6th day and 9th day during fasting, 3 days and 8 days after resuming diet) in hospital 4. Urine acid is measured by biochemistry method in hospital at six timepoints (3 days before fasting, the 3rd day, 6th day and 9th day during fasting, 3 days and 8 days after resuming diet) 5. Body compostion measured by dual-energy X-ray absorptiometry (DEXA) or sfb7 at three timepoints (3 days before fasting, 6th day during fasting 10 days after resuming diet) 6. Blood routine examination in hospital at six timepoints (3 days before fasting, the 3rd day, 6th day and 9th day during fasting, 3 days and 8 days after resuming diet) 7. Psychological mood is measured using the Profle of Mood State (POMS), Visual Analogue Scales (VAS), Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Work Ability Index (WAI), Stanford Sleepiness Scale (SSS) at six timepoints (3 days before fasting, the 3rd day, 6th day and 9th day during fasting, 3 days and 8 days after resuming diet | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hormones and cytokines measured by ELISA or biochemistry at six timepoints (3 days before fasting, the 3rd day, 6th day and 9th day during fasting, 3 days and 8 days after resuming diet) 2. Resting metabolic rate is measured by indirect calorimetry at five timepoints (2 days before fasting, 3rd and 9th day during fasting, 3 days and 7-8 days after resuming diet) | — |
Countries
China
Outcome results
None listed