Analysis of brain protective effects of different drugs in neurosurgery

Analysis of the effects of general intravenous anesthesia and combined inhalation anesthesia on regional cerebral oxygen saturation and brain protection during carotid endarterectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN17014575

Enrollment

Registered

2024-06-10

Start date

2019-07-01

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reduce the occurrence of postoperative complications in surgical patients Surgery

Interventions

Patients undergoing unilateral carotid endarterectomy (CEA) in the hospital will be randomly assigned to two groups, Group A (general intravenous anesthesia) and Group B (combined inhalation anesthesi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients classified as grade II or III according to the criteria of the American Society of Anesthesiologists (ASA) 2. No restrictions on age or sex 3. Unilateral carotid artery stenosis indicated by transcranial angiography (=70% stenosis in asymptomatic patients or =50% stenosis in symptomatic patients) 4. Capable of autonomous behavior 5. Voluntarily signing an informed consent

Exclusion criteria

Exclusion criteria: 1. Acute phase of cerebrovascular disease 2. Carotid artery occlusion 3. Non-visualization of distal carotid artery stenosis 4. Persistent neurological deficits 5. Long-term use of sedatives or antidepressants 6. Systemic consumptive diseases 7. Severe arrhythmias; myocardial infarction, heart failure, or poorly controlled severe hypertension 8. Severe diseases of the respiratory system

Design outcomes

Primary

Measure	Time frame
The heart rate (HR), percutaneous cerebral oxygen saturation (SpO2), mean arterial pressure (MAP), and SrO2 are measured using the recording of data through the monitor and the recording of test results 5 min before induction of anesthesia (T0), 5 min before carotid artery clamping (T1), immediately after clamping (T2), 5 min after clamping (T3), 10 min after clamping (T4), 15 min after clamping (T5), and 15 min after the restoration of the carotid artery blood flow (T6)	—

Measure

Time frame

The heart rate (HR), percutaneous cerebral oxygen saturation (SpO2), mean arterial pressure (MAP), and SrO2 are measured using the recording of data through the monitor and the recording of test results 5 min before induction of anesthesia (T0), 5 min before carotid artery clamping (T1), immediately after clamping (T2), 5 min after clamping (T3), 10 min after clamping (T4), 15 min after clamping (T5), and 15 min after the restoration of the carotid artery blood flow (T6)

—

Secondary

Measure	Time frame
Arterial blood gas analysis and S100-ß protein detection measured using the recording of data through the monitor and the recording of test results in blood samples collected at T1, T6, and 24 h after surgery (T7)	—

Countries

China

Contacts

Public ContactAikebaier Nuermaimaiti

ekber506@163.com+86 18699159288

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026