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The usefulness of cranberry syrup versus antibiotic prophylaxis with trimethoprim in infantile recurrent urinary tract infection

Randomised, double-blind analysis of the usefulness of cranberry syrup versus antibiotic prophylaxis with trimethoprim in infantile recurrent urinary tract infection

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16968287
Enrollment
210
Registered
2011-03-10
Start date
2009-01-01
Completion date
Unknown
Last updated
2017-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent urinary tract infection Urological and Genital Diseases Urinary tract infection

Interventions

Experimental group receive an evening dose of 3 ml of cranberry syrup which ensures a fixed concentration of 36 mg of proanthocyanidins. The administration is done before dinner. If vomiting occurs wi

Sponsors

Carlos III Institute of Health (Instituto de Salud Carlos III) (Spain)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Children 0 to 5 years consulting for any of the points 2, 3 and 4 of this paragraph, on any visits to specialists of the Hospital Virgen de las Nieves, Clínico San Cecilio de Granada and Baza County Hospitals and Motril 2. More than a urinary tract infection confirmed by urine culture (> 100,000 colonies/ml) and sediment with more than 20 leukocytes per field, in a urine sample collected on the prowl or urine collection bag after urethral meatus asepsis with chlorhexidine 3. Existence of any degree vesicoureteral reflux confirmed by cystography or dilatation of the renal pelvis or urinary tract confirmed by ultrasound 4. Existence of any anatomical abnormality of the urinary tract that current protocols of action to justify continued antibiotic prophylaxis

Exclusion criteria

Exclusion criteria: 1. Coexistence of other infectious diseases 2. Coexistence of metabolic diseases 3. Renal failure 4. Hepatic impairment 5. Existence of allergy or intolerance to any component of cranberry or trimethoprim 6. I want to show the legal responsibility not to participate in the study

Design outcomes

Primary

MeasureTime frame
Recurrence of urinary tract infection

Secondary

MeasureTime frame
Secondary resistance to antibiotics

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 25, 2026