Obesity hypoventilation syndrome, chronic hypercapnic respiratory failure Respiratory
Conditions
Interventions
At baseline, all patients were assessed for meeting the inclusion criteria, including history, physical examination, anthropometry, transthoracic echocardiography (Aloka, Tokyo, Japan), spirometry (Ga
Sponsors
University of Pavol Jozef Šafárik
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinically stable patients with OHS and severe hypercapnia during the daytime 2. Referred to the tertiary clinic for the initiation of long-term NIV to alleviate chronic respiratory failure
Exclusion criteria
Exclusion criteria: 1. Inability to provide written informed consent 2. Neuromuscular, chest wall, or metabolic disease resulting in hypercapnia 3. Acute respiratory tract infection 4. Chronic obstructive pulmonary disease (COPD) 5. Systolic LV failure as evidenced by LV ejection fraction <45% on transthoracic echocardiography
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac output (in litres per minute), stroke volume (in milliliters), and heart rate (in beats per minute) measured by impedance cardiography (ICG) at baseline, and after 3 and 12 months of using noninvasive ventilation for treatment of chronic respiratory failure | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical markers analysed in venous blood: serum troponin 1 (pg/ml), N-terminal pro-B-type natriuretic peptide (pg/ml), tumor necrosis factor-alpha (pg/ml), and interleukin-6 (pg/ml), measured at baseline, and after 3 and 12 months of using non-invasive ventilation for treatment of chronic respiratory failure | — |
Countries
Slovakia
Contacts
Public ContactPavol Pobeha
Outcome results
None listed