Dental sensitivity after applying cold saline water during endodontic treatment

Evaluation of cryotherapy and its effect on postoperative pain relief in single and bi-radicular teeth treated endodontically with and without foraminal enlargement

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16939754

Enrollment

180

Registered

2022-09-28

Start date

2022-06-01

Completion date

Unknown

Last updated

2024-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Single and bi-radicular teeth diagnosed with pulpal necrosis Oral Health

Interventions

After applying the inclusion criteria, teeth will be selected and treated, which will be distributed into eight groups. 1. HIV-negative patients treated without foraminal enlargement 2. HIV-negative p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Only single or biradicular teeth with a negative response to vitality tests will be considered, but with a diagnosis of pulp necrosis, with or without the presence of images suggestive of periapical lesions.

Exclusion criteria

Exclusion criteria: 1. Patients with acute apical pain 2. Pregnant patients 3. Patients with continuous use of corticosteroids, analgesics or antibiotics 4. Teeth with previous root canal treatment 5. Vital teeth 6. Anatomical foramen with a larger diameter with a type K #20 instrument or smaller with a type K #10 instrument 7. Teeth with root resorption that compromises the apical region

Design outcomes

Primary

Measure	Time frame
Pain intensity will be evaluated using a visual analogue scale (VAS), considered valid and reliable, from 0 to 10, where 0, 1–2, 3–7 and 8–10 means complete absence of pain, mild pain, moderate pain. and severe pain, respectively. Prior to the induction of local anesthesia, patients will be asked to record preoperative pain on the VAS to confirm the complete absence of pain. Postoperative pain was verified at 6, 12, 24, 48 and 72 hours and 7 days after endodontic treatment.	—

Measure

Time frame

Pain intensity will be evaluated using a visual analogue scale (VAS), considered valid and reliable, from 0 to 10, where 0, 1–2, 3–7 and 8–10 means complete absence of pain, mild pain, moderate pain. and severe pain, respectively. Prior to the induction of local anesthesia, patients will be asked to record preoperative pain on the VAS to confirm the complete absence of pain. Postoperative pain was verified at 6, 12, 24, 48 and 72 hours and 7 days after endodontic treatment.

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Brazil

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026