Changes in lean and skeletal muscle body mass in adult females with anorexia nervosa (AN) before and after weight restoration

Changes in lean and skeletal muscle body mass in adult females with anorexia nervosa (AN) before and after weight restoration: a longitudinal study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN16872194

Enrollment

180

Registered

2015-05-06

Start date

2010-01-10

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia nervosa/body composition Mental and Behavioural Disorders Anorexia nervosa

Interventions

1. Weight restoration 2. Inpatient cognitive behavioural therapy (CBT)

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Aged 18–45 2. Diagnosis of AN 3. Body mass index (BMI) =18.5 kg/m² at baseline 4. BMI =18.5 kg/m² at end of the treatment

Exclusion criteria

Exclusion criteria: 1. Participants with active substance abuse 2. Participants with schizophrenia or other psychotic disorders

Design outcomes

Primary

Measure	Time frame
Changes in lean body mass (LBM) and LBM distribution (extremity and trunk) measured by dual-energy X-ray absorptiometry (DXA) scan before and after weight restoration: 1. Total fat mass (FM): total fat mass in kilograms 2. Total FM percentage (%FM): total FM/total body weight x 100 3. LBM = total lean mass in kilograms 4. LBM percentage (%LBM) = LBM/total body weight x 100 5. Lean trunk mass percentage = lean trunk mass/lean body mass x 100 6. Lean extremity mass percentage = (lean arms mass + lean legs mass)/ lean body mass x 100 7. Lean trunk to extremity ratio = lean trunk mass percentage/lean extremity mass percentage	—

Measure

Time frame

Changes in lean body mass (LBM) and LBM distribution (extremity and trunk) measured by dual-energy X-ray absorptiometry (DXA) scan before and after weight restoration: 1. Total fat mass (FM): total fat mass in kilograms 2. Total FM percentage (%FM): total FM/total body weight x 100 3. LBM = total lean mass in kilograms 4. LBM percentage (%LBM) = LBM/total body weight x 100 5. Lean trunk mass percentage = lean trunk mass/lean body mass x 100 6. Lean extremity mass percentage = (lean arms mass + lean legs mass)/ lean body mass x 100 7. Lean trunk to extremity ratio = lean trunk mass percentage/lean extremity mass percentage

—

Secondary

Measure	Time frame
Changes in skeletal muscle (SM) with the use of a DXA-validated predictive model (SM = (1.19 x ALM) – 1.01) before and after weight restoration: 1. Appendicular (extremities) lean mass (ALM) in kilograms 2. Total body SM (kg)	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026