Taste acceptance of fluoride varnish on autistic patients

Quantitative analysis on the taste perception of different flavoured fluoride varnish on patients with autistic spectrum disorder (ASD)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16862566

Enrollment

Registered

2025-03-01

Start date

2019-06-01

Completion date

Unknown

Last updated

2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preventive dental care in autistic children Oral Health

Interventions

The taste acceptance of the fluoride varnish compounds Duraphat® (Colgate, New York, NY, USA), Profluorid® (VOCO GmbH, Cuxhaven, Germany), and MI varnish® (GC Europe N.V., Leuven, Belgium) are investi

Eligibility

Sex/Gender

All

Age

3 Years to 15 Years

Inclusion criteria

Inclusion criteria: 1. 3-15-year-old autistic children 2. Children with previous or current caries experience who were indicated for fluoride varnish application based on caries risk assessment

Exclusion criteria

Exclusion criteria: 1. Coexistence of diseases that may affect taste assessment (type 1 diabetes, infectious diseases 2. 2. Requiring antibiotic therapy, neoplastic diseases) 3. Oral thrush and injuries of the oral mucosa 4. Ulcerative gingival stomatitis 5. Lack of informed consent 6. Voluntary withdrawal of the parent or legal guardian at any stage of the procedure 7. Previous hospital admission for uncontrolled asthma 8. History of dental care provided in sedation or general anesthesia 9. Known sensitivity to colophony (Duraphat®, Profluorid®) 10. Milk protein or hydroxybenzoate allergy (MI varnish®)

Design outcomes

Primary

Measure	Time frame
(Negative or positive) non-verbal behavior measured using the Frankl behavior rating scale immediately after the application of fluoride varnish (Phase II)	—

Secondary

Measure	Time frame
1. Non-verbal behavior (subjective feedback) measured/collected using a three-point smiley rating scale after fluoride varnish application (after fluoride varnish application, each child was additionally asked to choose the appropriate smiley face from the three-point hedonic scale [phase III] which closely represents their evaluation of the taste of flavored fluoride varnish received by them) 2. Non-verbal behavior of each subject measured using the Frankl Behavior Rating Scale, before fluoride varnish application (Phase I)	—

Measure

Time frame

1. Non-verbal behavior (subjective feedback) measured/collected using a three-point smiley rating scale after fluoride varnish application (after fluoride varnish application, each child was additionally asked to choose the appropriate smiley face from the three-point hedonic scale [phase III] which closely represents their evaluation of the taste of flavored fluoride varnish received by them) 2. Non-verbal behavior of each subject measured using the Frankl Behavior Rating Scale, before fluoride varnish application (Phase I)

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Countries

United Kingdom, Wales

Contacts

Public ContactRohini Mohan

rohini.mohan@wales.nhs.uk+44 (0)7946402069

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026