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Platelet rich fibrin effects on third molar surgery

Effect of platelet rich fibrin on edema and pain following third molar surgery: A split mouth control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16849867
Enrollment
30
Registered
2017-03-10
Start date
2012-09-03
Completion date
Unknown
Last updated
2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bilateral impacted third molars Oral Health Bilateral impacted third molars

Interventions

Participants are selected based off their need for the removal of bilaterally (right-left) impacted mandibular third molars. Prior to the procedure, participants have blood collected. After placing

Sponsors

Ankara University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Healthy patients without significant medical diseases or a history of bleeding problems 2. Symmetrical impacted third molars which feature the same level of surgical difficulty that require the same surgical technique to be performed 3. The third molars in the Class I, Level B position (according to Pell &Gregory) and in the vertical positions according to Winter 4. Aged 17–27 years

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating women 2. Signs of pericoronitis 3. Chronic use of medications such as antihistamines, non-steroidal anti-inflammatory drugs (NSAID), steroids and antidepressants which would complicate the evaluation of their postoperative response

Design outcomes

Primary

MeasureTime frame
Pain is measured using a visual analogue scale (VAS) and Verbal rate scale (VRS) at 6 and 12 hours and 1, 2, 3 and 7 days after surgery.

Secondary

MeasureTime frame
Edema is measured using a flexible ruler at baseline, 2 and 7 days.

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026