Breast cancer Cancer
Conditions
Interventions
Single-centre interventional single-blinded randomised controlled trial.
Random allocation using a computer-generated random allocation program. All staff and patients will be masked to the group al
Sponsors
City St George's, University of London
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Female gender as determined at birth 2. Age 18 years and above 3. Primary breast cancer 4. Unilateral disease 5. Bilateral disease (DCIS in each breast) 6. Unifocal disease in each breast 7. Breast cancer which is DCIS on pre-operative histology, no invasive component 8. First diagnosis of primary breast cancer in that breast 9. Eligible for breast conserving therapy 10. Standard wide local excision technique 11. No previous radiotherapy to the breast 12. Demonstrates capacity to consent as assessed by their primary clinician 13. The perioperative use of any lesion localisation method including but not restricted to metal wires, localisation seeds (Magseed® Endomag), intraoperative use of the Faxitron (free standing x-ray machine) or other specimen x-ray machines
Exclusion criteria
Exclusion criteria: 1. Male gender 2. Patients with multifocal disease that requires mastectomy 3. Communication issues or limited English. 4. Previous breast cancer in the ipsilateral breast that has undergone the following treatments: endocrine therapy, WLE/radiotherapy 5. WLE that would include therapeutic mammoplasty and chest wall perforator flaps 6. Patients undergoing WLE under local anaesthetic 7. Patients that have had previous cosmetic augmentation/corrective surgery or reduction mammoplasty
Countries
England, United Kingdom
Contacts
Public ContactSarah;Buket Tang;Ertansel
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Outcome results
None listed