The effect of local anaesthetic and adrenaline injection on pain relief after a total hip replacement

PANTHER trial: Efficacy of peri-articular injection in total hip replacement for pain relief. a single-centre, double-blinded randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16846898

Enrollment

128

Registered

2026-04-14

Start date

2025-10-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain relief for patients undergoing a total hip replacement for osteoarthritis. Musculoskeletal Diseases

Interventions

Patients undergoing total hip arthroplasty under spinal anaesthetic were recruited for the study and prospectively randomised into groups

A & B. Treatment allocations were randomised using sealed opaque envelopes. Group A will receive the periarticular injection which will be administered to the agreed protocol by the surgeon during the

50ml anterior to the acetabular cup, 50ml to the psoas compartment and 50ml to the subcutaneous tissues. Group B will not receive the periarticular injection. Patients will be consented on the morning

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patient over 18 years old with osteoarthritis who have been scheduled for total hip arthroplasty

Exclusion criteria

Exclusion criteria: 1. Patients <18 years old 2. Patients with cognitive impairment 3. Previous diagnosis of a pain syndrome 4. Patient’s undergoing bilateral total hip arthroplasty or revision total hip arthroplasty

Countries

Ireland

Contacts

Public ContactRoss Condell

rosscondell@rcsi.com+353 1 814 0400

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 1, 2026