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Mutations with survival and recurrence in resected liver cancer

Association of IDH1 mutations with survival and recurrence in resected intrahepatic cholangiocarcinoma received or not received adjuvant chemotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN16843951
Enrollment
803
Registered
2023-01-30
Start date
2021-01-01
Completion date
Unknown
Last updated
2023-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intrahepatic cholangiocarcinoma Cancer

Interventions

Our research is an observation study. No intervention was involved in the course of the study. We collected tissue samples from patients attending the Department of Pathology of Zhongshan Hospital. Th

Sponsors

Zhongshan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age >20 years old 2. Male/female 3. Primary Intrahepatic Cholangiocarcinoma in patients who received curative resection

Exclusion criteria

Exclusion criteria: 1. Patients receiving palliative surgeries, prior interventions or with other primary malignancies and inflammatory diseases during the follow-up were excluded from the study 2. Patients with further lymph node involvement were considered to have distant metastasis and were excluded from the study.

Design outcomes

Primary

MeasureTime frame
1. Disease-free survival (DFS), defined as the interval between the surgery and any diagnosis of recurrence, measured using data collected every 3 months in the clinical information database of Zhongshan Hospital at one timepoint 2. Overall survival (OS), defined as the time from the date of surgery until death or to the end of follow-up, measured using data collected every 3 months in the clinical information database of Zhongshan Hospital at one timepoint

Secondary

MeasureTime frame
Gene mutation measured using whole-exome sequencing or Sanger sequencing at one timepoint

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026