Screening for Group B Streptococcus colonisation in pregnant women Infections and Infestations
Conditions
Interventions
The study population includes women who present to the labor ward of Queen Elizabeth Central Hospital, Blantyre Malawi. Trained Research Midwife Nurses approach the women to provide information about
Sponsors
Queen's University Belfast
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Pregnant women in active labour at a gestational age greater than 34 weeks (=4 cm dilated and regular contractions) The researchers will also aim to identify and recruit women who present to the labour ward with premature rupture of membranes (PROM), but who are not yet in labour (<4 cm dilated). If recruited into the study, they will only be tested for GBS when labour begins (=4 cm dilated and regular contractions).
Exclusion criteria
Exclusion criteria: 1. Preterm labour with estimated gestation <34 weeks as the obstetric management highly variable in this group, including the administration of tocolytic drugs 2. Labour with an estimated fetal size of <2 kg (as a proxy for gestational age, which may not be reliable) 3. Presentation in labour with cervical dilation =8cm as there is little likelihood of achieving testing and IAP before they deliver
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colonisation with Group B Streptococcus measured using the loop-mediated isothermal amplification assay (LAMP) during labour at hospital admission | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Results turnaround time from sample collection (vaginal and rectal swabs) to the administration of ampicillin in those positive for Group B Streptococcus 2. Concentration of ampicillin in cord blood at delivery measured using high-performance liquid chromatography (HPLC) in GBS-positive women given ampicillin | — |
Countries
Malawi
Outcome results
None listed