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Comparing collagen to collagen and hyaluronic acid in healing after impacted lower third molars surgical extraction

Effect of collagen and hyaluronic acid on healing after impacted lower third molars surgical extraction. (A clinical and radiographic study)

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16820104
Enrollment
20
Registered
2021-07-06
Start date
2020-10-01
Completion date
Unknown
Last updated
2021-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical extraction of symmetrical Impacted lower third molars Oral Health

Interventions

This study is a split mouth randomized clinical trial. The patient chose a piece of coin to decide which side was to be applied collagen and which was to be applied collagen and hyaluronic acid in soc

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The patient's age (18-35) years. 2. Surgical extraction of symmetrically impacted lower third molars is indicated. 3. Good general health and there are no uncontrolled systemic diseases. 4. The integrity of the periodontal tissues and the absence of periodontal diseases. 5. Good oral health. 6. There is no allergy or contraindication to the required postoperative prescription or to the applied medicinal substances.

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Diabetes mellitus 3. Hypertension 4. Compromised immune system or other systemic diseases 5. Patients with pericoronitis, infection, pathological condition in the region of surgery

Design outcomes

Primary

MeasureTime frame
At 3 days, 7 days, 1 month, 3 months, and 6 months: 1. Pain intensity measured using visual analogue scales (VAS) 2. Facial swelling (clinical evaluation) 3. Mouth opening (clinical evaluation) 4. Soft tissue healing (clinical evaluation)

Secondary

MeasureTime frame
Radial density measured using periapical digital radiographs at 1 month, 3 months and 6 months

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026