Comparison of school and community-based mass drug administration delivery strategies for control of Schistosoma mansoni infections in western Kenya in areas with >25% prevalence

Conditions

Schistosomiasis Infections and Infestations Schistosomiasis due to Schistosoma mansoni [intestinal schistosomiasis]

Shen Y, King CH, Binder S, Zhang F, Whalen CC, Evan Secor W, Montgomery SP, Mwinzi PNM, Olsen A, Magnussen P, Kinung'hi S, Phillips AE, Nalá R, Ferro J, Aurelio HO, Fleming F, Garba A, Hamidou A, Fenwick A, Campbell CH, Colley DG.

2017-09-2915 citations

10.1186/s12879-017-2738-5

Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries.

Ezeamama AE, He CL, Shen Y, Yin XP, Binder SC, Campbell CH, Rathbun S, Whalen CC, N'Goran EK, Utzinger J, Olsen A, Magnussen P, Kinung'hi S, Fenwick A, Phillips A, Ferro J, Karanja DM, Mwinzi PN, Montgomery S, Secor WE, Hamidou A, Garba A, King CH, Colley DG.

2016-05-2655 citations

10.1186/s12879-016-1575-2

Interventions

In the first step, in-depth parasitological surveys are carried out to identify 150 schools where the prevalence of S. mansoni (i.e., number of infections) amongst schoolchildren is greater than 24%.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Schoolchildren, either male or female, aged 9-12 years, attending the selected schools (in each study year) 2. First-year students, either male or female, attending the selected schools (in years 1 and 5) 3. Written informed consent signed by parents or legal guardians of the schoolchildren 4. Oral assent from schoolchildren 5. At least one stool sample provided over three consecutive days from 9- to 12- year-old children each study year 6. At least one stool sample provided from first-year students and adults in years 1 and 5

Exclusion criteria

Exclusion criteria: 1. Children not aged 9-12 years (in years 2, 3 and 4) 2. Adults in Years 2, 3 and 4 2. Children under 9 in Years 2, 3, 4 3. No written informed consent by parents or legal guardians of schoolchildren 4. No oral assent given by schoolchildren 5. No stool sample provided (for 9- to 12-year-old children in each study year; for first-year students and adults in years 1 and 5)

Design outcomes

Primary

Measure	Time frame
Identification of the most cost-effective strategy that is able to reduce S. mansoni infection from high prevalence levels, measured by change in prevalence and intensity of Schistosoma mansoni infection in 9- to 12-year-old children over the four years of intervention.	—

Secondary

Measure	Time frame
1. Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren, using Kato-Katz thick smears 2. Prevalence and intensity of S. mansoni infections in first-year schoolchildren, using Kato-Katz thick smears 3. Control of morbidity due to S. mansoni (reduction of the prevalence to <10%) in the 150 schools 4. Identification of S. mansoni risk factors 5. Mapping and prediction of the distribution of S. mansoni in Western Kenya Measured by changes in force of transmission, as assessed by infection prevalence and intensity of S. mansoni in first-year students and adults.	—

Measure

Time frame

1. Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren, using Kato-Katz thick smears 2. Prevalence and intensity of S. mansoni infections in first-year schoolchildren, using Kato-Katz thick smears 3. Control of morbidity due to S. mansoni (reduction of the prevalence to <10%) in the 150 schools 4. Identification of S. mansoni risk factors 5. Mapping and prediction of the distribution of S. mansoni in Western Kenya Measured by changes in force of transmission, as assessed by infection prevalence and intensity of S. mansoni in first-year students and adults.

—

Countries

Kenya

Contacts

Public ContactPauline Mwinzi

Pmwinzi@kemri.org+254 (0)721 308 588

Outcome results

None listed