An integrated neuromuscular training intervention applied in primary schools induces epigenetic modifications in disease-related genes

An integrated neuromuscular training intervention applied in primary schools induces epigenetic modifications in disease-related genes: A genome-wide DNA methylation study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16744821

Enrollment

Registered

2024-09-27

Start date

2017-10-01

Completion date

Unknown

Last updated

2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study population is apparently healthy school-aged children. Not Applicable

Interventions

Schools are randomly assigned as a control or intervention school. An integrated neuromuscular training intervention is applied in the intervention schools during the physical education classes as a w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. No evidence of chronic or acute illness in the month preceding potential enrollment 2. Age between 7 and 9 years

Exclusion criteria

Exclusion criteria: 1. Major congenital abnormalities 2. Illness or chronic use of medication 3. Musculoskeletal, neurological disorder and/or a medication therapy that could alter postural stability and cardiorespiratory function 4. Attending fewer than 80 % of the physical education classes

Design outcomes

Primary

Measure	Time frame
DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention	—

Secondary

Measure	Time frame
Physical fitness and fundamental motor skills are assessed through validated and standardized testing batteries: 1. Endurance – assessed with 800 m run test before and after the intervention 2. Speed and agility – assessed with Shuttle run 10 x 5 m test before and after the intervention 3. Explosive power of legs - assessed with the standing long jump test before and after the intervention 4. Handgrip strength – assessed with an analog hand dynamometer (TKK 5001, Grip-A, Takei, Tokyo, Japan) before and after the intervention 5. Flexibility – assessed with the sit-and-reach test before and after the intervention 6. Balance – assessed with the closed eyes bipedal test performed on a Wii balance board platform before and after the intervention 7. Fundamental motor skills (locomotor, control and manipulative) – assessed with the CAMSA test before and after the intervention	—

Measure

Time frame

Physical fitness and fundamental motor skills are assessed through validated and standardized testing batteries: 1. Endurance – assessed with 800 m run test before and after the intervention 2. Speed and agility – assessed with Shuttle run 10 x 5 m test before and after the intervention 3. Explosive power of legs - assessed with the standing long jump test before and after the intervention 4. Handgrip strength – assessed with an analog hand dynamometer (TKK 5001, Grip-A, Takei, Tokyo, Japan) before and after the intervention 5. Flexibility – assessed with the sit-and-reach test before and after the intervention 6. Balance – assessed with the closed eyes bipedal test performed on a Wii balance board platform before and after the intervention 7. Fundamental motor skills (locomotor, control and manipulative) – assessed with the CAMSA test before and after the intervention

—

Countries

Spain

Contacts

Public ContactAnna Prats-Puig

aprats@euses.cat+34 972 40 51 30

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026