Dry age-related macular degeneration Eye Diseases
Conditions
Interventions
Participants will hold a device emitting 670 nm light to their eyes for two minutes every day for one year and have their retinal function measured before, during and 1, 3, 6 and 12 months after.
Sponsors
University College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with dry AMD and healthy aged subjects 2. Aged 50 years and above
Exclusion criteria
Exclusion criteria: 1. Co-existent ocular disease: any ocular condition is present such that, in the opinion of the investigator, might affect the inflammatory status, visual acuity or cone function during the course of the study 2. A substantial cataract that, in the opinion of the investigator, is likely to be decreasing visual acuity by 3 lines or more (e.g. cataract would be reducing acuity to 6/12 or worse if eye was otherwise normal) and early cataract that might be susceptible to growth under the influence of 670 nm light 3. History of major ocular surgery (including cataract extraction, scleral buckle, any intraocular surgery, etc.) within prior 3 months or anticipated within the next 6 months following enrolment 4. Epilepsy 5. Allergies to adhesives or any other component used
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual function determined by photoreceptor function over time, measured at 1, 3, 6 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at 1, 3, 6 and 12 months: 1. Metrics of photoreceptor function, assessed psychophysically and electrophysiologically 2. Visual acuity and low-luminance acuity 3. Light-adapted 30 Hz flicker peak time, measured using a RETeval device 4. Anatomical changes, evaluated using SD OCT, autofluorescence and colour photographs 5. Safety and compliance of 670 nm light exposure | — |
Countries
United Kingdom
Outcome results
None listed