Gastrointestinal function Digestive System
Conditions
Interventions
Participants are randomised to one of three treatment arms for six weeks:
1. A capsule containing a probiotic strain A
2. A capsule containing a probiotic strain B
3. A placebo capsule with no probiot
Sponsors
Chr. Hansen A/S (Denmark)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy men or women 2. Age 18 to 40 inclusive 3. Presence of upper or lower gastrointestinal symptoms that interfere with training and during competition 4. Weekly training load of 4 or more hours within endurance sports (minimum 50% of the training should be running activity)
Exclusion criteria
Exclusion criteria: 1. History of hypersensitivity to any of the ingredients of the study products or lactose intolerance 2. History or diagnosis of gastrointestinal disease or complicated gastrointestinal surgery 3. Any physical or psychological abnormality or medical condition that could have an effect on gastrointestinal discomfort 4. Participation in any other clinical study 5. Not willing or able to provide written informed consent for participation in the study 6. For women: Not willing and able to use a reliable contraceptive method, pregnancy, lactation or wish to become pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal permeability after a standardized exercise challenge measured by the in vivo lactulose/rhamnose sugar test at baseline and end of intervention (after 6 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple potential biomarkers measured in blood, feces and saliva at baseline and end of intervention (after 6 weeks) | — |
Countries
Sweden
Outcome results
None listed