Impact of brewer's yeast (beta-glucan supplementation) on body status and muscle damage after exercise stress

The effect of yeast beta-glucan (Saccharomyces cerevisiae) supplementation on muscle damage, inflammatory markers, changes in mood and muscle function following a bout of treadmill exercise in a hot and humid environment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16680414

Enrollment

Registered

2020-04-02

Start date

2018-06-21

Completion date

Unknown

Last updated

2020-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recovery from stressful exercise Not Applicable

Interventions

Subjects will supplement with either 250 mg/day of yeast beta-glucan or a maltodextrin placebo for 13 days. Participants will arrive fasted and complete a bout of treadmill exercise at 55% VO2Max in

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Performing some form of aerobic exercise at least twice per week for the last 12 months 2. Have a VO2Peak between the 50th and 80th percentile for their age and gender

Exclusion criteria

Exclusion criteria: 1. Any individual who is currently being treated for or diagnosed with a cardiac, respiratory, circulatory, musculoskeletal, metabolic, immune, autoimmune, psychiatric, hematological, neurological or endocrinological disorder or disease. 2. Any individual being obese (defined as body mass index > 30 kg/m² and body fat greater than 30%) 3. Any female who is pregnant or breast-feeding 4. Any individual less than 18 and greater than 50 years of age

Design outcomes

Primary

Measure	Time frame
1. Indicators of muscle damage pre, immediately after, 2h and 72 hours post-exercise: 1.1. Perceived soreness measured using a 100-mm visual analog scale anchored with 0 – ‘No Soreness At All’ and 100-‘Extreme, Debilitating Soreness’ 1.2. Plasma creatine kinase measured using blood sample 1.3. Plasma myoglobin measured using blood sample 2. Cytokines (IL-1ß, IL-6, IL-12, GM-CSF, TNF-a, IL-2, IL-7, IL-13, IFN-?, IL-4, IL-8, IL-17, MCP-1, IL-6, IL-10, G-CST, and MIP-1ß) measured using blood sample assay pre, immediately after, 2h and 72 hours post-exercise 3. Muscle function (maximal voluntary isometric contraction tests and a 50-repetition isokinetic muscle fatigue test): pre, immediately after, 2h and 72 hours post-exercise 4. Mood state measured using profile of mood states (POMS): pre, immediately after, 2h and 72 hours post-exercise 5. Indicators of physiological stress (heart rate, RPE, VO2, and core temperature values): up to 60 minutes or until reaching a core temperature of 39.2°C	—

Measure

Time frame

1. Indicators of muscle damage pre, immediately after, 2h and 72 hours post-exercise: 1.1. Perceived soreness measured using a 100-mm visual analog scale anchored with 0 – ‘No Soreness At All’ and 100-‘Extreme, Debilitating Soreness’ 1.2. Plasma creatine kinase measured using blood sample 1.3. Plasma myoglobin measured using blood sample 2. Cytokines (IL-1ß, IL-6, IL-12, GM-CSF, TNF-a, IL-2, IL-7, IL-13, IFN-?, IL-4, IL-8, IL-17, MCP-1, IL-6, IL-10, G-CST, and MIP-1ß) measured using blood sample assay pre, immediately after, 2h and 72 hours post-exercise 3. Muscle function (maximal voluntary isometric contraction tests and a 50-repetition isokinetic muscle fatigue test): pre, immediately after, 2h and 72 hours post-exercise 4. Mood state measured using profile of mood states (POMS): pre, immediately after, 2h and 72 hours post-exercise 5. Indicators of physiological stress (heart rate, RPE, VO2, and core temperature values): up to 60 minutes or until reaching a core temperature of 39.2°C

—

Secondary

Measure	Time frame
Safety (Complete Blood Count and Comprehensive Metabolic Panel): pre, immediately after, 2h and 72 hours post-exercise	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026