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Cellular stress and effects on mitochondrial DNA

Cellular stress and effects on mitochondrial DNA: an assessment of stress reduction and protective factors

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16624353
Enrollment
30
Registered
2025-07-18
Start date
2025-05-29
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy female students who are subjected to normal stress Other

Interventions

Participants are randomized using a computer random number generator on Microsoft Excel to either a mindfulness meditation audio (30 minutes) or an educational podcast on tariffs and economic activity

Sponsors

York University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Females between 18 and 30 years of age 2. Maintain residency in Canada 3. General good health as defined by no history of asthma, current cancer diagnosis or treatment, myocardial infarction, and systematic immune diseases 4. Non-smokers

Exclusion criteria

Exclusion criteria: 1. Pregnant and/or lactating women 2. Current or previous (during the last 3 months) diagnosable or self-reported mental health problems 3. Chronic or acute physical disabilities or injuries 4. Current intake of prescribed medications that may interfere with endocrine, nervous and immune system operations (the only exceptions are oral contraceptives) 5. No antibiotic use, known infections and vaccination symptoms 6. No new tattoos within 2 weeks of the blood withdrawal

Design outcomes

Primary

MeasureTime frame
ccf-mtDNA levels within blood measured using quantitative polymerase chain reaction (qPCR), specifically following the MitoQuicLy protocol, at baseline (pre-stress time 0) and after the conduct of comparison interventions (mindfulness meditation audio, podcast audio) and the lab stress induction and a 20-minute rest period. The final blood draw follows the initial blood draw after the above activities, which in total sum up to 70 minutes.

Secondary

MeasureTime frame
Mood measured using the Profile of Mood States (POMS) at baseline (pre-stress time 0) and after the conduct of comparison interventions (mindfulness meditation audio, podcast audio) and the lab stress induction and a 20-minute rest period. The final mood state measures follow the activities described above, which sum up to 70 minutes.

Countries

Canada

Contacts

Public ContactJasmin Tiwana
jasmin56@my.yorku.ca+1 (0)416 736 2100 ext 22396

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026