Parkinson’s disease Nervous System Diseases
Conditions
Interventions
In this cross-over placebo-controlled trial, participants (n=15) will perform an exercise test on a fixed-power cycle ergometer in which they begin cycling for 5 minutes at 100 Watts, after which the
product code: SY648352. Each participant will perform the test twice, once after consuming the ketone drink and once after consuming the control drink. The two tests will be separated by a one-week wa
Sponsors
TdeltaS Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Parkinson's disease 2. Hoehn and Yahr stages 1-2 3. Fluent in English 4. Capable of giving informed consent 5. Aged 40-80 years
Exclusion criteria
Exclusion criteria: 1. Communication impairments 2. History or indications of cardiovascular disease 3. Any other disorder that the Principal Investigator deems may bias the study results or put the participant at risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Time to exhaustion (Te) 2. Maximum wattage achieved by participants (Wmax) 3. Maximum heart rate (HRmax) assessed by heart rate monitor worn during the test 4. Oxygen consumption (VO2max) assessed using a respiratory gas capture face mask worn during the test 5. Respiratory exchange ratio (RER) assessed using respiratory gas capture face mask worn during the test. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood glucose level 2. Blood lactate level 3. Blood free fatty acid level 4. Blood beta-hydroxybutyrate level These will be measured using samples taken from a venous cannula inserted into one of the participants’ arms immediately before consuming the study drink, immediately before exercise (30 minutes after consuming the study drink), and immediately after exercise. | — |
Countries
United Kingdom
Contacts
Public ContactNicholas Norwitz
Outcome results
None listed