Bartonella bacilliformis infection Infections and Infestations Bartonella bacilliformis infection
Conditions
Interventions
Participants are randomly allocated to one of two groups using random computer generation of a scheme, blocked in groups of ten to ensure similar numbers will be assigned to each group.
Group 1: Adul
Sponsors
Uniformed Services University of the Health Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 1 and 60 years 2. Clinical presentation compatible with Verruga peruana (chronic verrucous stage of Bartonellosis) 3. Able to provide informed consent/parental informed consent for children
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Use of oral contraceptives 3. Breast-feeding 4. Admission to the hospital for an unrelated condition 5. Use of antibiotics within the month preceding potential enrollment in the trial 6. Chronic use of alcohol 7. Known chronic liver disease 8. Use of medications that potentially interact with rifampin or azithromycin during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Time to resolution of verrucous lesions is measured from photographs and physical examinations undertaken at baseline, 7, 14, 30 and 60 days 2. Time to resolution of Bartonella bacteremia is measured through blood culture and PCR undertaken at baseline, 7, 14, 30 and 60 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Risk factors for Bartonella bacteremia measured using a questionnaire at baseline 2. Characteristics for clinical and laboratory findings associated with rash and Bartonella bacteremia measured at baseline, 7, 14, 30 and 60 days | — |
Countries
Peru
Outcome results
None listed