Monkeypox Infections and Infestations
Conditions
Interventions
Multicentre mixed-methods observational cohort study of case households and non-household contacts using paired serology, exposure data and perception interviews, and cross-sectional animal and enviro
Sponsors
London School of Hygiene & Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed mpox cases and all their household members (defined as people living together within the same residential structure and sharing meals) and up to five non-household close contacts will be invited to take part regardless of age, sex, pregnancy, smallpox vaccine status, language, or any other variable. 2. Wild rodents/small mammals in and around the case household will be trapped for sampling (unless pregnant or lactating). Cats and dogs in the case household and neighbouring households will also be sampled. All animal trapping and sampling will be done with relevant household consent.
Exclusion criteria
Exclusion criteria: There are no exclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Household incidence and secondary transmission estimated by qPCR (cases) and orthopox serology (asymptomatic or un-diagnosed contacts) at baseline and day 28 following household enrolment, taking into account previous smallpox vaccination. 2.Symptomatic, pauci-symptomatic and asymptomatic fractions of mpox infection based on orthopox serology and symptom questionnaires, at baseline and day 28 following household enrolment. 3.Identification of key risk factors and drivers of human mpox infection using risk ratios derived from individual exposure questionnaires in cases, household members and non-household close contacts carried out at baseline and covering a period of 1 month prior to household enrolment, and at day 28 following household enrolment covering the period since enrolment in the study. 4.Evidence of active and past infection in animals in the vicinity of a case household identified using PCR and serology on blood, tissue and swab samples at the time point of sampling. 5.Evidence of extent of surface contamination in case households using qPCR on samples taken on day 1 and day 3 after household enrolment. Cultures will be done on the same samples if resources allow. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Identification of barriers to and enablers for mpox prevention and control using themes derived from qualitative information gained using semi-structured household interviews on day 28 following household enrolment and covering the period since the household became aware of mpox. The period will vary depending on household experience. 2. Description of case household knowledge, experience and perceptions of mpox from qualitative information gained using semi-structured household interviews on day 28 following household enrolment and covering the period since the household became aware of mpox. The period will vary depending on household experience. 3. Identification of possible reservoirs of mpox virus using serology results by species derived from samples taken at one time point. | — |
Countries
Nigeria
Contacts
Public ContactChioma Achi
Outcome results
None listed