Malignant pleural effusion Cancer Malignant pleural effusion NOS
Conditions
Interventions
Screening:
1. Identification of patients attending Pleural Clinic for therapeutic aspiration
2. Contact participants via telephone to let them know about the study and provide them with a patient info
Sponsors
Norfolk and Norwich University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Aged 18 years or above 3. Diagnosed with pleural effusion on CT or ultrasound (US) 4. Patient attending for therapeutic aspiration (large volume drainage) of their pleural effusion: there is no specific minimal pleural fluid volume but this should be larger than required for diagnosis alone (typically 60 ml is taken for diagnostic purposes) 5. Known or suspected malignancy as the underlying cause of the effusion 6. In the Investigator’s opinion, is able and willing to comply with all study requirements
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or lactating 2. Pleural infection or other condition requiring admission and chest drain insertion 3. Known transudative pleural effusion or pleural effusion thought to be primarily due to cardiac, renal or hepatic impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The size of pleural effusion measured using chest X-ray on day 0 and day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers measured at baseline: 1. Patient biomarkers (e.g. duration of symptoms in days) measured using questionnaires 2. Effusion biomarkers (e.g. volume of fluid drained) measured using data recorded during the drainage procedure 3. Pleural fluid biomarkers (e.g. total protein) measured using standard laboratory analysis 4. Serum biomarkers (e.g. CRP) measured using standard laboratory analysis | — |
Countries
England, United Kingdom
Outcome results
None listed