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Comparison of using two doses of ephedrine to reduce low blood pressure with propofol for general anaesthesia

A comparison of two prophylactic doses of ephedrine to attenuate the hemodynamic responses in adults receiving propofol in general anaesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16564032
Enrollment
87
Registered
2021-09-28
Start date
2016-01-01
Completion date
Unknown
Last updated
2021-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attenuation of hemodynamic responses of propofol during induction of general anesthesia in adult patients. Surgery

Interventions

Patients were allocated into each group based on a randomised lot system. Group S1 included 29 patients who received normal saline intravenously as placebo just before induction, followed by propofol.

Sponsors

St.John's National Academy of Health Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adults between the ages of 20-59 years undergoing elective surgery under general anaesthesia. 2. ASA I and II patients.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. Patients allergic to study medication 3. Uncontrolled cardiovascular, respiratory, renal, or hepatic disease. 4. Morbid obesity. 5. Pregnant patients

Design outcomes

Primary

MeasureTime frame
Heart rate, systolic and diastolic blood pressure, and mean arterial pressure were measured using continuous monitoring equipment before induction and 2min after induction. Following intubation, the parameters were recorded at 1min, 3min, 5min, 10min, 15min and 30 min.

Secondary

MeasureTime frame
Intubating conditions evaluated according to the good clinical practice in pharmacodynamic studies of neuromuscular blocking agents ii: the Stockholm revision guidelines at the time of intubation

Countries

India

Contacts

Public ContactNayanthara Joachim
nayanthara1@yahoo.co.in+91-9844769469

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026