Improving tuberculosis treatment by high-energy biscuits in Mwanza, Tanzania

Improving Efficacy and Safety of TB and HIV Treatment by Nutritional Supplementation in Mwanza, Tanzania: A prospective, randomised, open labelled study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16552219

Enrollment

100

Registered

2010-09-22

Start date

2010-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis with and without HIV co-infection Infections and Infestations Respiratory tuberculosis, bacteriologically and histologically confirmed

Interventions

Patients will be randomised to either: 1. Intervention group: Five high energy biscuits containing 1000 kcal plus vitamins, minerals zinc and selenium every day during the intensive phase of the anti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Sputum smear positive TB patients 2. > 15 years old

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Age 48 hours) 5. Receiving antiretroviral therapy 6. Not willing to participate

Design outcomes

Secondary

Measure	Time frame
1. Improved immune recovery (CD4 increase) and decline in HIV RNA load in the intervention group 2. Improved and faster increase in lean body mass and physical strength 3. Less reporting of adverse effects	—

Primary

Measure	Time frame
Increase in TB drug exposure (AUC) during the first two months in the group receiving intervention compared to the group receiving standard care.	—

Countries

Tanzania

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026