Prevention of ventilator-associated pneumonia (VAP) in adult patients receiving invasive mechanical ventilation in the intensive care unit (ICU) Respiratory
Conditions
Interventions
Randomisation process:
Sequence generation: The random number table method, using SPSS 26.0 to generate the random allocation sequence.
Allocation concealment: The group assignments were placed in se
each session includes routine oral care plus tongue coating cleaning with a tongue scraper.
Comparator group (control group):
Oral care performed twice daily (at 8:00 and 20:00) using 80 ml of 0.12%
Sponsors
Affiliated Hospital of Hebei University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged =18 years old 2. Underwent orotracheal intubation and invasive mechanical ventilation treatment, and the expected ventilation time was =48 hours 3. The score of Acute Physiology and Chronic Health Evaluation II (APACHE II) at admission was =12 points 4. There was no pulmonary infection before admission, and there were no new lesions on chest imaging 5. The patient or family members were informed and agreed to participate in the study
Exclusion criteria
Exclusion criteria: 1. Suffered from immunodeficiency diseases or had long-term use of immunosuppressants 2. Had severe damage to the oral mucosa, a history of oral surgery, or inhalation burns 3. Had undergone tracheal intubation within 24 hours before admission 4. Had severe liver and kidney failure (Child-Pugh class C or eGFR <30 ml/min) 5. According to the judgment of the attending doctor, the expected survival time was <7 days due to end-stage diseases and other reasons 6. Had active pulmonary infection or active infection in other parts 7. Had severe malnutrition (serum albumin <25 g/L) 8. Had a history of long-term alcoholism or drug abuse
Countries
China
Contacts
Public ContactYanhui Jia
Outcome results
None listed