Prolongation of orthostatic tolerance in patients with reflex syncope Other
Conditions
Interventions
Randomisation via an online tool to heat acclimation or controlled temperate exercise.
Heat acclimation intervention (Visits 5-12: Randomly assigned to this group)
Active heat acclimation
On these vi
Sponsors
Leeds Beckett University
Eligibility
Sex/Gender
All
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-44 years 2. Regularly compete in endurance based exercise (=3 times a week and/or =5-hours a week). Have not been heat acclimated or been exposed to hypoxic conditions within the last 3 months (i.e. trained or competed in environmental temperatures of =25°C or altitude =2500m) 3. A non-smoker, with no history of cardiovascular or respiratory problems
Exclusion criteria
Exclusion criteria: 1. Suffered previously from heat illness (i.e. nausea, loss of consciousness or dizziness) 2. Any ankle, knee, leg, hip or back problems 3. History of cardiovascular or respiratory problems such as severe asthma. 4. Diagnosed with medical conditions such as diverticulitis, inflammatory bowel disease, gag reflex disorders or impairments. 5. Suffering from diarrhoea, haemorrhoids, bleeding tendencies, constipation, or intestinal complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Orthostatic tolerance using a tilt test with lower body negative pressure at Visit 1 (baseline) and Visit 14 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Performance time trial (TT) (20km completed as quickly as possible) Visits 4 (baseline) and 13 2. Physiological and perceptual responses measured by a heat stress test ((45 minutes of fixed intensity (2.5W.kg-1) exercise on a cycle ergometer, under hot-humid conditions (32? & 70% RH) with measurement of heart rate, core temperature, sweat rate, perceived exertion and thermal sensation)) at visit 5(baseline) 9 and 12. | — |
Countries
England, United Kingdom
Contacts
Public ContactDan Snape
Outcome results
None listed