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A study on wound healing using a novel bone graft after third molar removal surgery

A comparative study on the bone formation and soft tissue healing at distal surface of mandibular second molar following removal of the mandibular third molar using carbonate apatite bone graft

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16490429
Enrollment
21
Registered
2026-05-15
Start date
2026-02-09
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Soft tissue defect and bone defect (Periodontal defect) on distal surface of lower second molars due to presence of lower third molars Oral Health

Interventions

This study has a split-mouth double-blind design, in which all participants will undergo the same treatment (left and right lower third molar removal), but the intervention site (platelet-rich fibrin

Sponsors

University of Malaya
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Patient who requires surgical removal of bilateral impacted sound lower third molars 2. Impacted bilateral third molars as Class I or II with Level A or B according to Pell and Gregory's classification 3. Presence of disease free lower second molars adjacent to lower third molars planned for extraction 4. Patient aged 18-35 years old who are medically fit

Exclusion criteria

Exclusion criteria: 1. Impacted lower third molars associated with fracture of angle of mandible, radiological evidence of cyst or tumour, incomplete root formation, acute pulpitis or severe pericoronitis that is not under control or gross dental caries with ICDAS 05/06 2. Retained roots of lower third molar with history of removal or coronectomy of unerupted or impacted lower third molar 3. Patients with periodontitis, active smoker 4. Patients with absence of lower second molars 5. Medically compromised patients 6. Pregnant women 7. Patient on oral contraceptives or long term steroids 8. Current or previous bisphosphonate therapy or history of radiotherapy to the jaws

Countries

Malaysia

Contacts

Public ContactZhong Zheng Koo
s2012870@siswa.um.edu.my+60125270225

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 30, 2026