The role of inflammation in the outcomes of retinopathy of prematurity

Correlation between Systemic Immun-Inflammation index and routine hemogram related inflammatory markers in prognosis of Retinopathy Of Prematurity (SII ROP)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN16473879

Enrollment

303

Registered

2020-08-14

Start date

2016-05-01

Completion date

Unknown

Last updated

2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinopathy of prematurity Eye Diseases Retinopathy of prematurity

Interventions

There is no intervention as this is an observational trial. All data will be obtained from the patient’s hospital file for premature participants without ROP, and with early-stage ROP, aggressive post

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Complete blood counts (CBC) measured both <72 h after birth and one month after birth 2. Delivered at gestational age of =35 weeks

Exclusion criteria

Exclusion criteria: 1. Sepsis proven in blood culture 2. Necrotizing enterocolitis 3. Hematological disease 4. Receiving blood product transfusion or steroid treatment

Design outcomes

Primary

Measure	Time frame
Significance of Systemic Immune-inflammation Index (SII) values in the development period of ROP measured from Complete blood count (CBC) at birth and one month after birth	—

Secondary

Measure	Time frame
Prediction of the development of ROP using white blood cell (WBC) ratios such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte (PLR) and Systemic Immune-inflammation Index (SII) values measured from Complete blood count (CBC) at birth and one month after birth	—

Countries

Turkey

Contacts

Public ContactMuberra Akdogan

mbrakdogan@yahoo.com+90 5052408229

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026