Cocaine dependence Mental and Behavioural Disorders Cocaine dependence
Conditions
Interventions
Informed, consenting adult participants will be randomised remotely by the Clinical Trials Unit Kings College, London to one of two conditions:
Experimental Group: Experiment: Baseline cocaine cravi
Sponsors
Kings College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult (between 18 and 50 years old) 2. English speaking 3. Current diagnosis for cocaine dependence (ICD-10) 4. Self-reported regular cocaine use (weekly) and cocaine-positive UDS during screening 5. Motivation to reduce or quit cocaine use
Exclusion criteria
Exclusion criteria: 1. Current diagnosis of post-traumatic stress disorder (DSM-5) 2. Current non-medical benzodiazepine or harmful alcohol use (>50 units per week men; >35 units women) 3. Use of heroin or cocaine in the 24 hours before first CRF session 4. Clinically significant on-going medical problems that might make participation unsafe 5. Acute housing instability 6. Uncontrolled serious psychiatric illness 7. Significant neuro-cognitive functioning (<18, Montreal Cognitive Assessment) 8. Pregnant or breast feeding 9. Current enrollment in an addiction treatment related clinical research study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in craving intensity. Measured using the craving experience questionnaire (CEQ-11), adapted for cocaine for this study, at weeks 1 and 4 post randomization. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Physiological parameters during the craving provocation and memory reconsolidation and cognitive restructuring sessions: pulse rate, heart rate variability, electrodermal activity and skin conductance response. Mean and peak values will be computed: Days 1 to 5 of the intervention period 2. Self-report of cocaine useis assessed using a modified time-line follow-back (calendar prompt) interview to record instances of cocaine use during the study at weeks 1, 4 and 12 post randomization 3. Urine toxicology screening (UDS). By instant result immunoassay device for cocaine metabolite (benzolyecgonine) and morphine (morphine 2000 assay) at weeks 1, 4 and 12 post randomization and days 1 to 5 of the intervention 4. Audio-visual recordings: On a voluntary basis, each CRF session will be audio and video recorded via CCTV at the CRF 5. Treatment retention is assessed by recording the number of experimental participants who complete the 5-day CRF programme | — |
Countries
England, United Kingdom
Contacts
Public ContactGarry Stillwell
Outcome results
None listed