Epilepsy Nervous System Diseases
Conditions
Interventions
Suitable patients will be identified by the epilepsy clinical multi-disciplinary team, from the established CUH epilepsy surgery pathway. We anticipate that the primary utility of 7T MRI in these pati
Sponsors
Cambridge University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >18 years 2. Drug-resistant focal epilepsy (DRFE), defined as focal epilepsy that remains refractory to treatment with anti-epileptic medication, defined as continuing to have seizures despite adequate trials of two medications over 2 years 3. A desire to have curative surgery (i.e. the patient is in an established epilepsy surgery pathway) 4. A decision by the treating epileptologist that finding a new lesion, or better characterising a lesion poorly visualised at 3T MRI, would make a material difference to patient treatment options
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. The presence of non-MRI-safe metal implants 3. Implanted medical devices not certified as compatible with ultrahigh-field MRI (e.g.cardiac pacemakers) 4. Lack of mental capacity to consent to study involvement 5. Severe claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether the parallel transmit 7T MRI scan changes the epilepsy multi-disciplinary team's management plan: the MDT management plan is recorded before and after review of 7T, and a decision is made on whether it has changed. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Epilepsy surgical outcomes in terms of seizure freedom and quality of life measures, assessed longitudinally after surgery using Engel and ILAE outcome scales and the Quality of Life in Epilepsy Inventory 2. Correlation between 7T MRI and stereotactic EEG and neuropathology findings | — |
Countries
England, United Kingdom
Outcome results
None listed