Essential hypertension Circulatory System Hypertension
Conditions
Interventions
One treatment period: Single-pill combination of Perindopril / Indapamide / Amlodipine versus free dual therapy by fixed dose combination of Perindopril / Indapamide and by Amlodipine
Sponsors
Institut de Recherches Internationales Servier (France)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men or women of any ethnic origin > or = 18 years old 2. Uncontrolled hypertension
Exclusion criteria
Exclusion criteria: 1. Pregnancy, breastfeeding or possibility of becoming pregnant during the study 2. Hypertension known to be resistant to diuretics or ACE inhibitors 3. Secondary hypertension 4. Complicated hypertension 5. Obesity 6. History of renal disease, ventricular rhythm disorders, atrial fibrillation, atrial flutter 7. Diabetes 8. Grapefruit juice is forbidden during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Supine systolic blood pressure (SBP) and diastolic blood pressure (DBP): Change from baseline to last post-baseline assessment 2. Supine blood pressure normalisation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Supine and standing SBP and DBP: Change from baseline to last post-baseline assessment 2. Supine and standing blood pressure normalisation at the last post-baseline assessment for each visit measurement 3. Adverse events 4. Blood and urine biochemistry 5. Haematology 6. Vital signs and physical examination 7. 12-lead electrocardiogram | — |
Countries
Russian Federation, Serbia
Outcome results
None listed