Cognitive deficits in patients previously treated for low grade glioma Mental and Behavioural Disorders
Conditions
Interventions
Only WP3 will be interventional for this study. This will involve 12 sessions of repetitive Transcranial Magnetic Stimulation (rTMS) over 4 weeks. Intermittent Theta Burst dual-target rTMS will be del
Sponsors
University of Liverpool
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: WP - Work Package For WP1: 1. Treated for low-grade glioma (grade 2 intrinsic glial tumour) from 2013 onwards at the Walton Centre NHS Foundation Trust 2. Adult patients (>18 years) at time of treatment For WP2: 1. Completed online assessments in WP1 2. Available post-operative volume MRI (T1 or FLAIR) For WP3: 1. Cognitive eligibility: Presence of objective or subjective cognitive deficits defined as >1 SD below the average on any CANTAB test or scoring <55/72 in the Perceived Cognitive Impairments subscale of FACT-Cog 2. Medical stability: no documented change to medical management (chemotherapy, radiotherapy, or surgery) within the last 3 months 3. The invited patients will be selected based on pairwise randomisation from patients who completed assessments in WP1. Pairwise randomisation will be used to balance the two groups on key predictor variables
Exclusion criteria
Exclusion criteria: For WP1: 1. No explicit exclusion criteria For WP2: 1. No explicit exclusion criteria For WP3: 1. Contraindications to strong magnetic fields (applicable to the TMS sessions and the MRI follow-up scans) 2. Active known pregnancy 3. Unable or unwilling to travel to the Sid Watkins building for TMS sessions 4. History of uncontrolled seizures
Countries
England, United Kingdom
Contacts
Public ContactAhmad Ali
Outcome results
None listed