Delaying early (first 72 hours) feeding and glucose-containing maintenance solutions in intensive care patients. Nutritional, Metabolic, Endocrine
Conditions
Interventions
Multicentre, open-label cluster-randomised crossover trial with ICU clusters. Each ICU is randomised to one of two sequences: AB (Intervention ? Control) or BA (Control ? Intervention). The method of
Sponsors
University of Tartu
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adult (=18 years) 2. Intensive Care Unit (ICU) admission (index admission to the participating ICU)
Exclusion criteria
Exclusion criteria: 1. The patient requires intravenous glucose infusion according to the attending clinician’s assessment 2. Acute or acute-on-chronic liver failure 3. Moderate hypernatremia ( >150 mmol/L) 4. Diabetic ketoacidosis or hyperosmolar hyperglycemic state at admission 5. Pregnancy 6. Exclusive end-of-life care (no other treatment goal than comfort care for end of life) 7. Organ donor 8. Prior enrolment in this trial during the same hospitalisation 9. Patients with a metabolic disease requiring specific diet and patients with clinical need for a ketogenic diet 10. Patients already enrolled in other interventional studies on nutrition, intravenous fluids, phosphate supplementation or hormonal therapies that influence glucose homeostasis
Countries
Austria, Belgium, Estonia, Germany, Netherlands, New Zealand, Saudi Arabia, Sweden, Switzerland, United States of America
Contacts
Public ContactKadri;Martin Tamme;Sundström Rehal
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Outcome results
None listed