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The ED-CO study: screening for carbon monoxide exposure in the emergency department

The ED-CO study: a prospective enhance surveillance study of carboxyhaemoglobin levels in patients attending the Emergency Department with symptoms suggestive of carbon monoxide exposure

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN16329899
Enrollment
5222
Registered
2019-11-25
Start date
2018-12-07
Completion date
Unknown
Last updated
2024-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carbon monoxide poisoning Injury, Occupational Diseases, Poisoning Accidental poisoning by and exposure to other gases and vapours

Interventions

Patients presenting to the Emergency Department will have blood taken for analysis, have baseline information recorded about their symptoms, and be screened using a questionnaire for carbon monoxide (

Sponsors

St George's University Hospitals NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years or older 2. Presenting to the ED with symptoms suggestive of cardiac chest pain, non-traumatic headache, flu-like symptoms unless suggestive of specific focus of infection, seizures or syncope/presyncope

Exclusion criteria

Exclusion criteria: 1. Aged under 18 years 2. Chest pain associated with chest wall tenderness or non-cardiac cause (pulmonary embolism, pneumothorax) 3. Recurrent situational syncope 4. Head injury 5. Actual or suspected smoke inhalation 6. Unable to understand the informed consent process and/or has a poor understanding of English (e.g. English-speaking relative/translator not available within timescales for study procedures) 7. Patients previously enrolled in this study

Design outcomes

Primary

MeasureTime frame
Carboxyhemoglobin (COHb) level in blood sample provided on day of presentation to Emergency Department

Secondary

MeasureTime frame
1. Answers to questions in the COMA screening questionnaire provided by patient on day of presentation to Emergency Department 2. Time of year of confirmed or suspected CO exposure (summer versus winter) assessed using patient medical records and gas engineer data following presentation 3. Diagnosis of dementia during the 28 days following presentation assessed using patient medical records

Countries

England, United Kingdom

Contacts

Public ContactDesislava Baramova
EDCOstudy@stgeorges.nhs.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026