Low bone mass Musculoskeletal Diseases Low bone mass
Conditions
Interventions
The participants were randomly assigned to a resistance exercise group (RG
n = 50), walking group (WG
n = 50), or control group (CG
n = 50).
Resistance exercise group: Participants take part in a single resistance training exercise session. This involves 8 minutes of dynamic warm-up consisting of exercises requiring movements of
Sponsors
University of Pécs
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Aged between 35 and 65 years 3. New diagnosis of osteoporosis/osteopenia 4. Lack of endocrine or metabolic disease which would have an impact on bone mineral density or musculoskeletal system 5. Normal lifestyle and activity 6. Agreement to participate 7. Generally considered to be healthy
Exclusion criteria
Exclusion criteria: 1. Any condition influencing calcium and bone metabolism (except dietary calcium and Vitamin D supplementation), 2. Ongoing hormone replacement therapy 3. Any known endocrine/metabolic, renal, or hepatic disease (e.g., hypogonadism, hyperthyroidism, hyperparathyroidism, or increased glucocorticoid levels) 4. Any physical injury (orthopedic, rheumatologic) hindering the performance of physical activity 5. Osseous fracture of any origin during the previous 6 months 6. A diagnosis of cardiovascular disease or uncontrolled hypertension 7. Any non-antibiotic medication within the past year, including steroids of any type, thyroid hormones, diuretics, or anticoagulants 8. Any antibiotic use within the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Bone-specific alkaline phosphatase (BALP) concentration is measured using a photometric assay at baseline and immediately after the intervention 2. Carboxy-terminal cross-linked telopeptide of type I collagen (CTX) concentration is measured using an electrochemiluminescence immunoassay (ECLIA) at baseline and immediately after the intervention 3. Serum sclerostin concentration is measured using a qualitative sandwich enzyme-linked immunosorbent assay (ELISA) at baseline and immediately after the intervention Several assistants performed sample collection simultaneously to ensure rapid collection within 0 –5 minutes after the exercise sessions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone mineral density (BMD) is determined by dual energy X-ray absorptiometry (DEXA) using a LUNAR DPX densitometer at baseline. | — |
Countries
Hungary
Contacts
Public ContactGabriella Császárné Gombos
Outcome results
None listed