Cardiac arrest Circulatory System Cardiac arrest
Conditions
Interventions
Current intervention as of 08/01/2024 to 11/07/2022:
This study will involve putting defibrillators into one of three groups to deliver one of the three different shock strategies in current UK use. A
Sponsors
University of Warwick
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 21/07/2023: 1. Patients suffering OHCA attended by a crew from participating ambulance service 2. Resuscitation attempted and shock delivered as per Resuscitation Council (UK) and JRCALC guidelines _____ Previous inclusion criteria: 1. Patients suffering OHCA attended by a crew from participating ambulance service 2. Resuscitation attempted and shock indicated as per Resuscitation Council (UK) and JRCALC guidelines
Exclusion criteria
Exclusion criteria: Patients known or suspected to be under 18 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 08/01/2024 to 21/07/2023: Recruitment rate calculated from the number of eligible participants and the number recruited by the end of the study _____ Previous primary outcome measure as of 21/07/2023: Recruitment rate calculated from the number of eligible participants and the number recruited in the study by 24 months _____ Previous primary outcome measure: Recruitment rate recorded as the number of eligible participants enrolled in the study by 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 31/07/2023: 1. Treatment adherence rate recorded as the proportion of patients receiving the allocated treatment prior to hospital admission 2. Data completeness of clinical outcomes, defined as the proportion of enrolled patients who by the end of trial have data relating to: 2.1. Return Of Organised Rhythm capable of sustaining a pulse (ROOR) assessed using defibrillator data recorded 2 min post-shock 2.2. Resulting rhythm (VF/pVT/PEA/asystole) assessed using defibrillator data recorded 2 min post-shock 2.3. Re-arrest rate (re-fibrillation) assessed using defibrillator data recorded during the out-of-hospital phase of resuscitation 2.4. Survived event (return of spontaneous circulation (ROSC)) using ambulance records at hospital handover 2.5. Survival assessed using hospital records at hospital discharge and at 30 days post cardiac arrest 2.6 Neurological outcomes (mRS score) measured using the Rankin Focused Assessment at hospital discharge and 30 days post cardiac arrest 3. Data completeness of process outcomes: 3.1. Quality of CPR (chest compression rate, chest compression depth, chest compression fraction, pre-shock pause, post-shock pause) measured using defibrillator data from the out-of-hospital phase of care 3.2. Number of shocks measured using defibrillator data from the out-of-hospital phase of care 3.3. Advanced airway applied (% advanced airway applied and % supraglottic airway or endotracheal tube) measured using patient clinical records from the out-of-hospital phase of care 3.4. Intravenous medicines administered (% cases where medicines administered and % adrenaline, amiodarone) measured using patient clinical records from the out-of-hospital phase of care 3.5. Transported to hospital (% transported) measured using Ambulance Service data from the out-of-hospital phase of care _____ Previous secondary outcome measures as of 21/07/2023: 1. Treatment adherence rate recorded as the proportion of patients receiv | — |
Countries
England, United Kingdom
Contacts
Public ContactJes Rai
Outcome results
None listed